Life Atomic: A History of Radioisotopes in Science and Medicine by Angela N. H. Creager

Author:Angela N. H. Creager
Language: eng
Format: epub, pdf
Published: 2014-06-15T16:00:00+00:00

purchased from Oak Ridge, Moore sought to challenge Whipple's theory that iron uptake was controlled by the intestinal mucosa and regulated by iron stores in the body.66 Moore used healthy subjects as well as patients in his investigations of how pernicious anemia affected hemoglobin and red blood cell synthesis.67 Other researchers examined how quickly radioiron (p.279)

Figure 8.3. Diagram showing how the accumulation of radioactivity in the human spleen over time was measured. At time zero, a subject would be given a dose of radioactive iron. The appearance of gamma radiation from the decaying radioiron would be measured by a scintillation counter directed at the spleen. In the chart at right, the rapid appearance of radioiron in the spleen of patients with polycythemia vera, in which red blood cells are overproduced, shows that short-lived cells were being formed (and degraded in the spleen) as well as normal red blood cells of a 120-day life span. In the case of refractory anemia, radioiron accumulates in the spleen as red blood cells are destroyed, but the breakdown products are then retained in the organ. From US Atomic Energy Commission, Eight-Year Isotope Summary, vol. 7 of Selected Reference Material, United States Energy Program(Washington, DC: US Government Printing Office, 1955), p. 10.

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